Sekar is a regular in S. S. Rajamouli's films and played a lawyer in Sye (2004). He garnered acclaim for his role as Prabhas's friend in Chhatrapati (2005). He has since portrayed notable roles in several Telugu films including Vikramarkudu (2006), Magadheera (2009), the bilingual Eega (2012), Rangasthalam (2018), the bilingual film U Turn (2018). He made his Tamil-language debut with Viswasam (2019), in which he portrayed Ajith Kumar's Muslim friend. He portrayed a farmer in the historical film Yatra and played one of the leads in Diksoochi (2019). He will play Jr. NTR's friend in the upcoming RRR.